SS-208 (C007B-417899)

SS-208 is a selective HDAC6 inhibitor, with an IC 50 of 12 nM. SS-208 possesses anti-tumor activity in melanomaIn VivoSS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously . Dosage: 25 mg/kg. Administration: IP on day 4, 7, 12, 15 and 18. Result: Significantly reduced the tumor growth.Form:SolidIC50& Target:HDAC6 12 nM (IC 50 ) HDAC8 1.23 μM (IC 50 ) HDAC1 1.39 μM (IC 50 ) HDAC11 5.12 μM (IC 50 ) HDAC5 6.91 μM (IC 50 ) HDAC7 8.34 μM (IC 50 ). Specification: 0.98 Molecular Formula: C13H11Cl2N3O4 Molecular Weight: 344.15 PubChem CID: 135348858 Isomeric SMILES: C1=CC(=C(C=C1C(=O)NCCC2=CC(=NO2)C(=O)NO)Cl)Cl

UPC:

51112513

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

S647126-25mg

CAS:

2245942-72-5

Product Size:

25mg