STREPTOLYSIN O GAMMA-IRRADIATED (C005B-377895)

Application

Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.

Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Biochem/physiol Actions

Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.

Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.

Unit Definition

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

Preparation Note

Prepared from S 5265

Shipping Information:

Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.

Dry Ice Surcharge & Ice Pack Shipments: $40

More Information: https://cenmed.com/shipping-returns

UPC:

51284044

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

Yes

Quantity:

25000

Unit of Measurement:

UN

MPN:

S0149-25KU

CAS:

98072-47-0

Temperature Control Device:

Yes