SU9516 (C008B-269517)

SU9516 is a 3-substituted indolinone compound displaying anti-proliferative and proapoptotic properties in tumor cells. SU9516 displays activity as a selectively potent ATP-competitive inhibitor of CDKs. It also shows no significant effect (IC|50|>10 μM) on the activities of PKC, p38, PDGFRβ, or EGFR. SU9516 has an Inhibitory effect on proliferation of growth-factor stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F. SU9516 is an inhibitor of Cdc2, Cdk2 and Cdk4.

a selectively potent ATP-competitive inhibitor of CDKs

Specifications & Purity: SU9516 is a 3-substituted indolinone compound displaying anti-proliferative and proapoptotic properties in tumor cells. SU9516 displays activity as a selectively potent ATP-competitive inhibitor of CDKs. It also shows no significant effect (IC|50|>10 μM) on the activities of PKC, p38, PDGFRβ, or EGFR. SU9516 has an Inhibitory effect on proliferation of growth-factor stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F. SU9516 is an inhibitor of Cdc2, Cdk2 and Cdk4.

Grade: Moligand™

Molecular Formula: C13H11N3O2

Molecular Weight: 241.25

PubChem CID: 24906268

Isomeric SMILES: COC1=CC2=C(C=C1)NC(=O)C2=CC3=CN=CN3

Storage Temperature: Protected from light;Store at -20°C;Desiccated

Shipped in: Ice chest + Ice pads

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S336668-SCI_a578bd6078562218b762bbf6095bac23.pdf

UPC:

42295167

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

S336668-100mg

Country of Origin:

China

CAS:

666837-93-0

Product Size:

100mg

Harmonized Tariff Code:

2931.90.90

Precautionary Statement Codes:

P264