Biochem/physiol Actions
SW063058 is an autophagy inducer that selectively disrupts Beclin 1/Bcl-2 binding, versus Bax/Bcl-2 binding. SW063058 acts by disrupting the binding of Bcl-2, a negative regulator of autophagy, to the BH3 domain of Beclin 1, which is involved in autophagy initiation. It does not inhibit Bcl-2 binding to the BH3 domain of the pro-apoptotic Bcl-2 family members BAX and BIM. In vitro experiments showed that SW063058 was not cytotoxic and induced autophagy without inducing apoptosis or other forms of cell death.
- UPC:
- 51285103
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SML2527-5MG
- CAS:
- 533876-30-1
- Controlled Substances and Cyanide:
- Yes
