Thiolutin (C007B-276766)

Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp. The compound has been shown to inhibit transcription in Saccharomyces cerevisiae and mRNA degradation. Thiolutin inhibits the adhesion of endothelial cells, including adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin, and restricts tumor cell-induced angiogenesis. Studies have reported that Thiolutin is an effective inducer of HSP 27 (heat shock protein 27; Hsp27) phosphorylation. Research shows that in the presence of Thiolutin, the interaction between Hsp27 and nestin is disrupted, which results in the breakdown of nestin filaments.An RNA polymerase inhibitor and suppressor of tumor cell-induced angiogenesis. Specification: 0.95 MDL Number: MFCD07370147 Molecular Formula: C8H8N2O2S2 Molecular Weight: 228.29 PubChem CID: 6870 Isomeric SMILES: CC(=O)NC1=C2C(=CSS2)N(C1=O)C Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T102393-SCI_01e2a31dd900526d8fa05c34aa329661.pdf

UPC:

12352204

Condition:

New

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

T102393-1mg

CAS:

87-11-6

Health Hazards:

Toxic

Product Size:

1mg

Hazard Statement Codes:

H300

Precautionary Statement Codes:

P264:P270:P330:P405:P501