TMX-4100 (C007B-431065)

TMX-4100 is a selective phosphodiesterase 6D ( PDE6D ) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC 50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myelomaIn VitroTMX-4100 (compound 3; 1 μM; 4 h) shows a high degradation preference for PDE6D in MOLT4 cells. TMX-4100 has better proteome-wide degradation selectivity in MOLT4 cells, compare to PDE6D degrader FPFT-2216. TMX-4100 does not impede the growth of KRAS-dependent cell lines (MIA PaCa-2, NCI-H358, AGS, PA-TU-8988T cells). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: MOLT4 cells Concentration: 1 μM Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D. Western Blot AnalysisCell Line: MOLT4, Jurkat, and MM.1S cells Concentration: 0 nM, 40 nM, 200 nM, 1 μM; Incubation Time: 4 hours Result: Showed a high degradation preference for PDE6D with the DC 50 value less than 200 nM.Form:SolidIC50& Target:PDE6 PDE6D. Specification: 0.98 Molecular Formula: C11H10N4O2S Molecular Weight: 262.29

UPC:

41116107

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

T650498-5mg

CAS:

2367619-63-2

Product Size:

5mg