TR antagonist 1 (C007B-430953)

TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC 50 s of 36 and 22 nM for TRα and TRβ, respectively.In VitroTR antagonist 1 displays high affinity for both thyroid hormone TRα and TRβ (IC 50 =36 and 22 nM, respectively). TR antagonist 1 acts as a full antagonist in the TRAFR cell assay and the IC 50 32 nM for both TRAFα1 and TRAFβ1. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoTR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 36 nM (Thyroid hormone α), 22 nM (Thyroid hormone α). Specification: 0.98 Molecular Formula: C25H23Br2NO4 Molecular Weight: 561.26 PubChem CID: 135528521 Isomeric SMILES: CC(C)C1=CC(=CC(=C1O)/C=C/C2=CC=NC=C2)OC3=C(C=C(C=C3Br)CCC(=O)O)Br

UPC:

51181621

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

T649933-10mg

CAS:

500794-88-7

Product Size:

10mg