UMI-77 (C007B-304824)

InformationUMI-77 UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.TargetsMcl-1 (Cell-free assay) 490 nM(Ki)In vitroUMI-77 effectively disrupts the interactions between BL-Noxa and cellular Mcl-1, as well as Mcl-1/Bax protein–protein interactions. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induced apoptosis in pancreatic cancer through activation of the intrinsic apoptotic pathway and/or Bax conformational change.In vivoIn a BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg i.v.) exhibits single-agent antitumor activity without any damage normal tissues.Cell Research(from reference)Cell lines：Human pancreatic cancer cell lines AsPC-1, BxPC-3, Panc-1, MiaPaCa and Capan-2 Concentrations：~100 μM Incubation Time：4 days. Specification: 0.98 Molecular Formula: C18H14BrNO5S2 Molecular Weight: 468.34 PubChem CID: 992586 Isomeric SMILES: C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/U413771-SCI_2a423770ef7c8a172d159fe3baef71b8.pdf

UPC:

51111758

Condition:

New

Weight:

0.97 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

U413771-100mg

CAS:

518303-20-3

Health Hazards:

Corrosive

Product Size:

100mg

Hazard Statement Codes:

H302:H315:H318:H335

Precautionary Statement Codes:

P261:P264:P270:P271:P280:P310:P302+P352:P305+P351+P338:P332+P313:P405:P403+P233:P501:P301+P312+P330:P304+P340+P312