Umibecestat (C007B-432065)

Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC 50 s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively Umibecestat can be used for the research of alzheimer's disease.In VitroUmibecestat (CNP520) is a potent BACE-1 inhibitor that is selective for BACE-1 over other human pepsin-like aspartic proteases, including BACE-2 and cathepsin D. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoUmibecestat (CNP520) (1.5-51.3 mg/kg; given by oral gavage; 72 hours) shows a dose-dependent effects on A²40 and a long duration of action in both rat brain and CSF . Umibecestat (CNP520) (3.1 mg/kg; oral administration; 7 days) shows a > 75% reduction on A²40 and A²42 in CSF after dosing and returns slowly to baseline over the next 7 days . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male rats (3-4 months old) Dosage: 1.5 mg/kg (3 M/kg)-51.3 mg/kg (100 M/kg) Administration: Given by oral gavage; 72 hours Result: Reduced 89.3±4.5% A²40 at the highest dose in brain tissue, and 50% lowering of rat brain A²40 (ED50) was 2.4±0.31 mg/kg. Reduced ~50% A²40 at a single oral 30 M/kg (15.4 mg/kg) dose after 24 hours in both rat brain and CSF€‚ Animal Model: 3-month-old beagle dogs Dosage: 3.1 mg/kg (6 M/kg) Administration: Oral administration; 7 days Result: Both A²40 and A²42 concentrations in CSF showed a > 75% reduction at 12-48 h after dosing and returned slowly to baseline over the next 7 days.Form:SolidIC50& Target:IC50: 11 nM (human BACE-1), 10 nM (mouse BACE-1). Specification: 0.99 Molecular Formula: C19H15ClF7N5O2 Molecular Weight: 513.8 PubChem CID: 88602735 Isomeric SMILES: C[C@]1(CO[C@@](C(=N1)N)(C)C(F)(F)F)C2=C(C=CC(=N2)NC(=O)C3=C(C=C(C=N3)C(F)(F)F)Cl)F

UPC:

51143004

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

U646410-10mg

CAS:

1387560-01-1

Product Size:

10mg