Voltage-gated Ca2+ channel blocker found in Catharanthus and precursor in synthesis of vinca alkaloids. It binds tubulin poorly, suppresses growth of Plasmodium, and decreases blood pressure and heart rate. (C003B-255125)

Catharanthine is an alkaloid found in Catharanthus that is a chemical precursor in the synthesis of vinca alkaloids such as vinblastine and vincristine. Catharanthine displays weak anti-mitotic activity, binding tubulin poorly. Catharanthine exhibits anti-parasitic, vasodilatory, and antihypertensive activities. This compound shows antimalarial benefit against species of Plasmodium. In vivo, catharanthine inhibits voltage-gated Ca2+ channel currents, decreasing blood pressure and heart rate. Grade: ≥97%

UPC:

51143011

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

C0378-25 mg