YTX-465 (C007B-433381)

YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC 50 s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson’s disease and other synucleinopathiesIn VitroYTX-465 (1-10000 nM) has an EC 50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue. YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast. YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop. YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM. YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Ole1 0.039 μM (IC 50 ) SCD1 30.4 μM (IC 50 ). Specification: 0.99 Molecular Formula: C25H26N6O3 Molecular Weight: 458.51 PubChem CID: 134477586 Isomeric SMILES: CC1=NN(C2=C1C=CC(=C2)C3=NOC(=N3)C4CCN(CC4)C(=O)CNC(=O)C5=CC=CC=C5)C

UPC:

51172466

Condition:

New

Weight:

1.06 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

Y646482-10mg

CAS:

2225824-53-1

Product Size:

10mg